                               SEQUENCE LISTING

<110> MCKAY, JOHN ANDREW
      WANG, WAN
      LAURIE, GORDON W.
 
<120> COMPOSITIONS AND METHODS FOR THE DELIVERY OF DRUGS TO THE OCULAR 
      SURFACE BY CONTACT LENSES

<130> 064189-6910

<140> PCT/US2014/032412
<141> 2014-03-31

<150> 61/806,558
<151> 2013-03-29

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
1               5                   10                  15      


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            20                  25                  30          


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        35                  40                  45              


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    50                  55                  60                  


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
65                  70                  75                  80  


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                85                  90                  95      


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            100                 105                 110         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        115                 120                 125             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    130                 135                 140                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
145                 150                 155                 160 


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                165                 170                 175     


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            180                 185                 190         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        195                 200                 205             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    210                 215                 220                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
225                 230                 235                 240 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                245                 250                 255     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            260                 265                 270         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        275                 280                 285             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    290                 295                 300                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
305                 310                 315                 320 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                325                 330                 335     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            340                 345                 350         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        355                 360                 365             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    370                 375                 380                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
385                 390                 395                 400 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                405                 410                 415     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            420                 425                 430         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        435                 440                 445             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    450                 455                 460                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
465                 470                 475                 480 


<210> 2
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
1               5                   10                  15      


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            20                  25                  30          


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        35                  40                  45              


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    50                  55                  60                  


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
65                  70                  75                  80  


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                85                  90                  95      


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            100                 105                 110         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        115                 120                 125             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    130                 135                 140                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
145                 150                 155                 160 


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                165                 170                 175     


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            180                 185                 190         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        195                 200                 205             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    210                 215                 220                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
225                 230                 235                 240 


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                245                 250                 255     


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            260                 265                 270         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        275                 280                 285             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    290                 295                 300                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
305                 310                 315                 320 


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                325                 330                 335     


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            340                 345                 350         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        355                 360                 365             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    370                 375                 380                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
385                 390                 395                 400 


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                405                 410                 415     


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            420                 425                 430         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        435                 440                 445             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    450                 455                 460                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
465                 470                 475                 480 


<210> 3
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
1               5                   10                  15      


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            20                  25                  30          


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        35                  40                  45              


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    50                  55                  60                  


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
65                  70                  75                  80  


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                85                  90                  95      


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            100                 105                 110         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        115                 120                 125             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    130                 135                 140                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
145                 150                 155                 160 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                165                 170                 175     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            180                 185                 190         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        195                 200                 205             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    210                 215                 220                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
225                 230                 235                 240 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                245                 250                 255     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            260                 265                 270         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        275                 280                 285             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    290                 295                 300                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
305                 310                 315                 320 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                325                 330                 335     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            340                 345                 350         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        355                 360                 365             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    370                 375                 380                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
385                 390                 395                 400 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                405                 410                 415     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            420                 425                 430         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        435                 440                 445             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    450                 455                 460                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
465                 470                 475                 480 


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 4
Val Pro Gly Xaa Gly 
1               5   


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 5
Val Pro Gly Ser Gly 
1               5   


<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
Val Pro Gly Val Gly 
1               5   


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Leu Val Pro Arg Gly Ser 
1               5           


<210> 8
<211> 119
<212> PRT
<213> Homo sapiens

<400> 8
Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala Gln Glu Ala 
1               5                   10                  15      


Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala Glu Pro Ala 
            20                  25                  30          


Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser Ala Ala Ala 
        35                  40                  45              


Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu Leu Asn Pro 
    50                  55                  60                  


Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu Gln Ala Leu 
65                  70                  75                  80  


Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly Gly Lys Gln 
                85                  90                  95      


Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys Lys Phe 
            100                 105                 110         


Ser Leu Leu Lys Pro Trp Ala 
        115                 


<210> 9
<211> 140
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (133)..(133)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 9
Met Gly Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala Gln 
1               5                   10                  15      


Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala Glu 
            20                  25                  30          


Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser Ala 
        35                  40                  45              


Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu Leu 
    50                  55                  60                  


Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu Gln 
65                  70                  75                  80  


Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly Gly 
                85                  90                  95      


Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys 
            100                 105                 110         


Lys Phe Ser Leu Leu Lys Pro Trp Ala Gly Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Tyr 
    130                 135                 140 


<210> 10
<211> 138
<212> PRT
<213> Homo sapiens

<400> 10
Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu 
                85                  90                  95      


Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
        115                 120                 125             


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
    130                 135             


<210> 11
<211> 406
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
catatggaag acgcttcttc tgactctacc ggtgctgacc cggctcagga agctggtacc       60

tctaaaccga acgaagaaat ctctggtccg gctgaaccgg cttctccgcc ggaaaccacc      120

accaccgctc aggaaacctc tgctgctgct gttcagggta ccgctaaagt tacctcttct      180

cgtcaggaac tgaacccgct gaaatctatc gttgaaaaat ctatcctgct gaccgaacag      240

gctctggcta aagctggtaa aggtatgcac ggtggtgttc cgggtggtaa acagttcatc      300

gaaaacggtt ctgaattcgc tcagaaactg ctgaaaaaat tctctctgct gaaaccgtgg      360

gctggtctgg ttccgcgtgg ttctggttac tgatctcctc ggatcc                     406


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Leu Val Pro Arg Gly Ser 
1               5           


<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Val Pro Gly Ser Gly Val Pro Gly Ile Gly Tyr 
1               5                   10          


<210> 14
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
1               5                   10                  15      


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
            20                  25                  30          


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
        35                  40                  45              


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
    50                  55                  60                  


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
65                  70                  75                  80  


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
                85                  90                  95      


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
            100                 105                 110         


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
        115                 120                 125             


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
    130                 135                 140                 


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
                165                 170                 175     


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
            180                 185                 190         


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
        195                 200                 205             


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
    210                 215                 220                 


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
225                 230                 235                 240 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
                245                 250                 255     


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
            260                 265                 270         


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
        275                 280                 285             


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
    290                 295                 300                 


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
305                 310                 315                 320 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
                325                 330                 335     


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
            340                 345                 350         


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
        355                 360                 365             


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
    370                 375                 380                 


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
385                 390                 395                 400 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
                405                 410                 415     


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
            420                 425                 430         


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
        435                 440                 445             


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
    450                 455                 460                 


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
465                 470                 475                 480 


Gly Tyr 
        


<210> 15
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
1               5                   10                  15      


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            20                  25                  30          


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        35                  40                  45              


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    50                  55                  60                  


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
65                  70                  75                  80  


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                85                  90                  95      


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            100                 105                 110         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        115                 120                 125             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    130                 135                 140                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
145                 150                 155                 160 


Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val 
                165                 170                 175     


Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro 
            180                 185                 190         


Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly 
        195                 200                 205             


Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser 
    210                 215                 220                 


Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly Val Pro Gly Ser Gly 
225                 230                 235                 240 


<210> 16
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
1               5                   10                  15      


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            20                  25                  30          


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        35                  40                  45              


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    50                  55                  60                  


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
65                  70                  75                  80  


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                85                  90                  95      


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            100                 105                 110         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        115                 120                 125             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    130                 135                 140                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
145                 150                 155                 160 


Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val 
                165                 170                 175     


Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro 
            180                 185                 190         


Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly 
        195                 200                 205             


Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile 
    210                 215                 220                 


Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly Val Pro Gly Ile Gly 
225                 230                 235                 240 


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Leu Val Pro Arg Gly Ser Gly 
1               5               


